Mesotherapy
The progression of time, environmental factors, stress, insomnia, and genetic predispositions directly affect our skin—the largest organ of our body—and our hair. The cosmetic creams or serums we use daily are insufficient to penetrate the skin barrier (epidermis) and reach the deeper layers. This is exactly where Mesotherapy, one of the most powerful non-surgical repair methods in medicine and aesthetics, comes into play.
First developed in 1952 by French doctor Michel Pistor, Mesotherapy is the process of injecting building blocks such as vitamins, minerals, amino acids, enzymes, antioxidants, and hyaluronic acid—which the skin and hair follicles desperately need—directly into the middle layer of the skin (mesoderm) using micro-needles. The fundamental philosophy of mesotherapy is to deliver the “right medicine, in the right amount, directly to the target.” Thanks to the personalized mesotherapy cocktails applied in our clinic, cellular renewal is triggered, collagen production increases, and the tissues repair themselves, achieving a natural, radiant, and youthful appearance.
In Which Areas and for Which Problems is Mesotherapy Applied?
With its wide range of applications, mesotherapy is considered the “Swiss Army Knife” of aesthetic dermatology. It provides excellent results in three main categories using special formulas prepared according to the individual’s needs:
1. Facial Mesotherapy (Mesolifting / Youth Vaccine)
It is applied to stop and reverse the signs of aging on the face, neck, décolletage, and the back of the hands.
- Skin Revitalization: Instantly provides intense moisture and a radiant glow to dull, dehydrated, and tired-looking skin.
- Wrinkle Treatment: Helps smooth out fine lines and increases skin elasticity.
- Pigmentation (Spot) Treatment: Treats color inequalities such as sun spots, age spots, and melasma (pregnancy mask) using special agents that suppress melanin production.
- Acne Scars and Pore Tightening: Initiates the repair process under the skin to narrow enlarged pores and lighten the appearance of acne scars.
2. Hair Mesotherapy
It is a gold-standard treatment for stopping hair loss (alopecia) seen in both men and women and improving hair quality.
- Stimulates dormant hair follicles by nourishing them directly.
- Thickens hair strands, prevents breakage, and adds volume to the hair.
- It is frequently applied as a supportive treatment before and after Hair Transplant operations to maximize the survival and holding rate of the transplanted grafts.
3. Body and Cellulite Mesotherapy
- Cellulite Treatment: Smooths the orange-peel appearance by injecting enzymes that break down degraded fat tissues and fibrotic bands under the skin, accelerating blood circulation.
- Targeted Fat Reduction (Lipolysis): Used to dissolve small, diet- and exercise-resistant fat deposits (double chin, abdomen, hips).
Comparative Table: Mesotherapy vs. PRP vs. Dermal Fillers
Aesthetic procedures can often be confused with one another. You can review the table below to understand the distinct difference of mesotherapy:
| Feature | Mesotherapy | PRP (Platelet Rich Plasma) | Dermal Fillers |
| Content | Externally prepared cocktails of Vitamins, Minerals, Peptides, Hyaluronic Acid, etc. | Repairing cells (Platelets) separated from the person’s own blood | Cross-linked, volumizing dense Hyaluronic Acid |
| Primary Goal | Nourish skin/hair, lighten spots, hydrate, increase cellular activity | Repair tissue damage, trigger wound healing and collagen production | Fill hollows, contour the face, provide volume |
| Application Frequency | Generally in courses of 4-6 sessions, spaced 1-2 weeks apart | 3-4 sessions, spaced 3-4 weeks apart | Single session (Repeated as the effect wears off) |
| Effect Process | Increases gradually with regular sessions | Seen progressively as sessions advance and collagen is produced | Effect is seen instantly (Immediately) upon application |
Step-by-Step Mesotherapy Application Process
Mesotherapy is a highly comfortable and brief medical aesthetic procedure that does not interrupt your daily life.
1. Analysis and Cocktail Preparation: Our specialist physician analyzes the needs of your skin or scalp. The most suitable combination of vitamins, amino acids, and enzymes (cocktail) for your age, skin type, and specific complaint is prepared exclusively for you.
2. Local Anesthesia: Local anesthetic (numbing) creams are applied to the procedure area to reduce the sensation of the micro-needles to zero, and we wait for 15-20 minutes.
3. Micro-Injection Phase: Using very fine, single-use mesotherapy needles or special “mesotherapy guns,” the prepared formula is injected into the middle layer of the skin at millimetric intervals. Depending on the size of the area, the session takes an average of 15-30 minutes.
4. Post-Procedure: It is normal to have slight redness or tiny mosquito bite-like bumps at the injection sites; this completely passes within a few hours. The patient can immediately return to work and social life. It is sufficient to avoid wearing makeup, washing with excessively hot water, and engaging in heavy sports on the day of the procedure.
Frequently Asked Questions (FAQ)
You can quickly access answers to the most common questions and find detailed information about the treatment process here.
Is the mesotherapy procedure painful?
Thanks to the highly effective topical anesthetic creams applied before the procedure and the use of needles even thinner than a strand of hair (30-32 G), the pain felt is virtually non-existent. Most of our patients describe the procedure merely as a slight “tingling” or “touching” sensation.
When do the effects of mesotherapy start to be seen?
Mesotherapy is a “course” treatment. After the first session, you will feel an increase in brightness and moisture in your skin, but the permanent effects such as true cellular renewal, lightening of spots, or stopping of hair loss generally become evident after the 2nd or 3rd session.
How many sessions of mesotherapy do I need to have?
The number of sessions varies according to the person’s age, the depth of the problem, and the application area (face, hair, body). Generally, 4 to 6 sessions are recommended at 1-2 week intervals for facial rejuvenation, and 6 to 8 sessions for hair loss treatments. Once the initial course is completed, “maintenance sessions” performed every 3-6 months prolong the permanence of the achieved results.
Are there any side effects of mesotherapy?
Since mesotherapy is performed with reliable, FDA-approved substances that have been used in medicine for many years, it has no systemic side effects. Temporary and very mild redness, and rarely minor bruising, may be seen in the procedure area solely due to needle entries. These disappear on their own within a few days. As a precaution, it is not applied to pregnant women, nursing mothers, and active patients undergoing cancer treatment.
Op. Dr. Sena Genç Elden
Otolaryngologist (ENT Specialist)
Op. Dr. Sena Genç Elden, following her medical and residency training, completed Facial Plastic Surgery School and gained experience as a chief physician; she possesses national and international clinical expertise alongside world-renowned surgeons and currently continues her practice at her own private clinic in Serdivan, Sakarya.
Give Your Skin and Hair the Youth Elixir They Need
Do not let dullness on your face, shedding hair, or stubborn skin spots steal your energy in the mirror. Go beyond superficial creams and defy time with our personalized mesotherapy cocktails that nourish your cells right at their core (mesoderm). To initiate the awakening of your own cells and achieve a natural, bright, and vibrant appearance, you can schedule your preliminary evaluation appointment with our expert physicians right away.
References and Scientific Basis
International Clinical Guidelines;
American Society of Plastic Surgeons (ASPS): Mesotherapy and Minimally Invasive Skin Rejuvenation.
Mayo Clinic: Hair Loss – Diagnosis and Treatment Options (Including Mesotherapy adjuncts).
Academic Publications (Surgeon Dr. Sena Genç Elden) ;
- Elden, S. G., et al. (2024). Diagnostic Value of the Video Head Impulse Test in Patients with Vertigo: Can It Be Used as a Screening Tool? ResearchGate
- Elden, S. G., & Güven, E. M. The Effect of Hypericum Perforatum L. (St. John’s Wort) on Prevention of Myringosclerosis After Myringotomy. ResearchGate
- Genç Elden, S., & Demir, D. Investigation of diclofenac sodium’s ototoxic and neurotoxic effects on the rat model. ResearchGate